We have been working with a team at University of Manchester, NHS England and the G4AGH Pharmacogenomics Working Group to develop some Pharmacogenetics (PGx) models to support clinical decision support in GP systems in the UK.
The resultant models are intended to capture both the specific lab test data, and the derived ‘PGx phenotype’ that is critical to triggering appropriate prescribing support. We did look at perhaps adapting the Precaution archetype but after discussion feels that a new archetype is more appropriate - see this page for background
We were planning to run some reviews on the Apperta CKM - see Project details but feel that this might be more appropriate to do internationally, though we will need to start the process very soon either way.
We have resource to support the editorial process if the Clinical Program Board / CKM admins agree that it is ok for us to run the reviews within the international CKM environment with some oversight e.g one of the CKM team joining as a reviewer
We would be interested to know if others are working in this space.
I’m in favour of doing this review in the international CKM, alternatively in parallel if there’s a requirement to do it in Apperta. Our experience from the Norwegian governance is that local → international doesn’t work, but international → local does work. So currently we operate on an “international first” principle.
Have the models been added as proposals in the international CKM?
The current practice is archetype proposal → quick editorial walkthrough → import to project → project editors get going with reviews.
If you’d upload a proposal, we can have the editorial walkthrough with you in a video meeting soon, and then reviews can start as soon as you’re ready?
Agree. @ian.mcnicoll - ultimately the process will be most efficient if the archetype proposed for review starts in alignment with the existing International archetype patterns. In my experience, it could save you a whole review round.
Hi Koray, the second review round of the Pharmacogenetic result archetype is now open on the CKM - your contribution would be much appreciated! Happy to have a chat if you’d like more information about the background and discussions from the first review round.
Hi there,
Just slipping in a remark: Nice to have as much reviewers as possible! In order to invite new reviewers, they have to be an user in the CKM. If “someone”, for example you Koray, as you know Mr. Kapool , could send him the instructions to do so. Here: Self-Registration in CKM - openEHR Clinical - Confluence (atlassian.net)
And then Heidi will invite him to the review as soon as he’s registered?
Agree. We actually have an email template ready for this which @heidi.koikkalainen will get over to you @Koray_Atalag . Much better if the intro comes from you.
Happy to have a chat if you’d like more information about the background and discussions from the first review round.