# Age - A reference that might help on age-related triggers

**Category:** [Clinical (archive)](https://discourse.openehr.org/c/clinical-archive/153)
**Created:** 2005-01-28 04:20 UTC
**Views:** 5
**Replies:** 2
**URL:** https://discourse.openehr.org/t/age-a-reference-that-might-help-on-age-related-triggers/14475

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## Post #1 by @lakewood

Hi All,

A reference that discusses age\-related triggers:

http://www.separationsnow.com/basehtml/SepH/1,1353,6-1-4-1-0-news_detail-0-619,00.html

\-experiments with yeast
\-compares with empirical eveidence re humans
\-yeast & humans:
"\.\.\. genetic instability shoots up dramatically in the middle to late stage of life\. "
\-yeast:
"\.\.\. equivalent of late middle age \.\.\. 200\-fold surge in the production of genetic changes \.\.\.
may be an ideal model for understanding the complexities of age\-related cancer development in humans\. "
\-"\.\.\. The discovery that an age\-dependent switch is somehow activated to trigger genomic instability could have major scientific consequences \.\.\."
\-"\.\.\. If researchers can determine the molecular mechanics that trip the switch, they one day may be able to develop drugs or gene\-replacement methods to prevent the switch from being thrown in the first place \.\.\."

"\.\.\. \*develop drugs or gene\-replacement methods to prevent the switch from being thrown\* \.\.\."

An industry in the making\. Should a procedure be developed for a Patient identifying the age
at which one or more triggers can occur it appears a natural consequence would be a total
re\-arrangement of life\-style coupled with a drug regimen to bypass the switch\.

My belief is that there a many potential 'mid\-course corrections' that can be hung off of
the generic key 'age'\. Additional 'qualifiers' may no longer suffice\.

Even if it proves 50% effective you have a 'real' industry building aroound it\. Patients will demand to know whattheir 'bad age' is\.

Regards\!

\-Thomas Clark

Ed Ermini wrote:

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## Post #2 by @Philippe_AMELINE1

Hi Thomas,

We have been deeply involved in such a process for nearly 3 years with a project named DPIO for Dépistage et Prévention Individuelle Organisée \(no official translation yet\)\.

We work in the following way :
\- Individual risk evaluation by the GP \(no mass process\)
\- Follow up \(or early lesions findings\) triggers
\- Management of all this over time on the Ligne de vie

What I can say is that the only age/sex trigger is "individual risk evaluation" ; other triggers depend on the risk level you just evaluated\.
However, all this process is very complex since you always have to balance the risk/benefit ratio of primary prevention\.

Cheers

Philippe

lakewood@copper\.net wrote:

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## Post #3 by @lakewood

Hi Philippe,

This appears to be a very significant project for age\-sensitive Patients of all
ages\. Diabetes Patients would represent one group that could benefit greatly from
'Individual risk evaluation' and subsequent 'risk management'\. In just a short
conversation with others each had at least one example of 'age\-related' and/or
'age\-dependent' Healthcare issues affecting family and friends\.

Regards\!

\-Thomas Clark

Philippe AMELINE wrote:

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**Original content:** https://discourse.openehr.org/t/age-a-reference-that-might-help-on-age-related-triggers/14475