# Age - A reference that might help on age-related triggers
**URL:** https://discourse.openehr.org/t/age-a-reference-that-might-help-on-age-related-triggers/14475
**Category:** Clinical (archive)
**Created:** [28 January 2005 04:20 UTC](https://discourse.openehr.org/t/age-a-reference-that-might-help-on-age-related-triggers/14475 "2005-01-28T04:20:27Z")
**Posts on this page:** 3
**Page:** 1
### Author:  [@lakewood](https://discourse.openehr.org/u/lakewood)
#### Post date: [28 January 2005 04:20 UTC](https://discourse.openehr.org/t/age-a-reference-that-might-help-on-age-related-triggers/14475/1 "2005-01-28T04:20:27Z")
Hi All,
A reference that discusses age-related triggers:
[http://www.separationsnow.com/basehtml/SepH/1,1353,6-1-4-1-0-news\_detail-0-619,00.html](http://www.separationsnow.com/basehtml/SepH/1,1353,6-1-4-1-0-news_detail-0-619,00.html)
-experiments with yeast
-compares with empirical eveidence re humans
-yeast & humans:
"... genetic instability shoots up dramatically in the middle to late stage of life. "
-yeast:
"... equivalent of late middle age ... 200-fold surge in the production of genetic changes ...
may be an ideal model for understanding the complexities of age-related cancer development in humans. "
-"... The discovery that an age-dependent switch is somehow activated to trigger genomic instability could have major scientific consequences ..."
-"... If researchers can determine the molecular mechanics that trip the switch, they one day may be able to develop drugs or gene-replacement methods to prevent the switch from being thrown in the first place ..."
"... \*develop drugs or gene-replacement methods to prevent the switch from being thrown\* ..."
An industry in the making. Should a procedure be developed for a Patient identifying the age
at which one or more triggers can occur it appears a natural consequence would be a total
re-arrangement of life-style coupled with a drug regimen to bypass the switch.
My belief is that there a many potential 'mid-course corrections' that can be hung off of
the generic key 'age'. Additional 'qualifiers' may no longer suffice.
Even if it proves 50% effective you have a 'real' industry building aroound it. Patients will demand to know whattheir 'bad age' is.
Regards!
-Thomas Clark
Ed Ermini wrote:
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### Author:  [@Philippe\_AMELINE1](https://discourse.openehr.org/u/Philippe_AMELINE1)
#### Post date: [28 January 2005 09:22 UTC](https://discourse.openehr.org/t/age-a-reference-that-might-help-on-age-related-triggers/14475/2 "2005-01-28T09:22:26Z")
Hi Thomas,
We have been deeply involved in such a process for nearly 3 years with a project named DPIO for Dépistage et Prévention Individuelle Organisée (no official translation yet).
We work in the following way :
- Individual risk evaluation by the GP (no mass process)
- Follow up (or early lesions findings) triggers
- Management of all this over time on the Ligne de vie
What I can say is that the only age/sex trigger is "individual risk evaluation" ; other triggers depend on the risk level you just evaluated.
However, all this process is very complex since you always have to balance the risk/benefit ratio of primary prevention.
Cheers
Philippe
lakewood@copper.net wrote:
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### Author:  [@lakewood](https://discourse.openehr.org/u/lakewood)
#### Post date: [28 January 2005 20:45 UTC](https://discourse.openehr.org/t/age-a-reference-that-might-help-on-age-related-triggers/14475/3 "2005-01-28T20:45:04Z")
Hi Philippe,
This appears to be a very significant project for age-sensitive Patients of all
ages. Diabetes Patients would represent one group that could benefit greatly from
'Individual risk evaluation' and subsequent 'risk management'. In just a short
conversation with others each had at least one example of 'age-related' and/or
'age-dependent' Healthcare issues affecting family and friends.
Regards!
-Thomas Clark
Philippe AMELINE wrote: